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Why Is the Duration of Erythema Migrans at Diagnosis Longer in Patients with Lyme Neuroborreliosis Than in Those without Neurologic Involvement?
Ogrinc, Katarina; Bogovic, Petra; Maraspin, Vera; Lotric-Furlan, Stanka; Rojko, Tereza; Kastrin, Andrej; Strle, Klemen; Wormser, Gary P; Strle, Franc.
Affiliation
  • Ogrinc K; Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
  • Bogovic P; Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
  • Maraspin V; Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
  • Lotric-Furlan S; Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
  • Rojko T; Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
  • Kastrin A; Institute for Biostatistics and Medical Informatics, University of Ljubljana, 1000 Ljubljana, Slovenia.
  • Strle K; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Tufts University, Boston, MA 02111, USA.
  • Wormser GP; Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA.
  • Strle F; Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
Pathogens ; 13(2)2024 Feb 01.
Article in En | MEDLINE | ID: mdl-38392875
ABSTRACT
In prior studies, the skin lesion erythema migrans (EM) was present for a longer time period before diagnosis of concomitant borrelial meningoradiculoneuritis (Bannwarth's syndrome) compared to EM patients without neurologic symptoms. To determine if this observation pertains to other manifestations of Lyme neuroborreliosis (LNB), we compared EM characteristics in patients with borrelial meningoradiculoneuritis (n = 122) to those with aseptic meningitis without radicular pain (n = 72 patients), and to patients with EM but without neurologic involvement (n = 12,384). We also assessed factors that might impact duration. We found that the duration of EM at diagnosis in patients with borrelial meningoradiculoneuritis was not significantly different compared with those with LNB without radicular pain (34 vs. 26 days; p = 0.227). The duration of EM for each of these clinical presentations of LNB, however, was significantly longer than in patients with EM without LNB (10 days; p < 0.001). Contributing factors to this difference might have been that patients with LNB failed to recognize that they had EM or were unaware of the importance of not delaying antibiotic treatment for EM. In conclusion, the duration of the EM skin lesion in EM patients with LNB is longer than in patients with just EM, irrespective of the type of LNB.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pathogens Year: 2024 Document type: Article Affiliation country: Slovenia

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pathogens Year: 2024 Document type: Article Affiliation country: Slovenia