The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders.
J Comp Physiol B
; 194(3): 253-263, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38396062
ABSTRACT
Individuals with neurodevelopmental disorders experience persistent sleep deficits, and there is increasing evidence that sleep dysregulation is an underlying cause, rather than merely an effect, of the synaptic and behavioral defects observed in these disorders. At the molecular level, dysregulation of the synaptic proteome is a common feature of neurodevelopmental disorders, though the mechanism connecting these molecular and behavioral phenotypes is an ongoing area of investigation. A role for eIF2α in shifting the local proteome in response to changes in the conditions at the synapse has emerged. Here, we discuss recent progress in characterizing the intersection of local synaptic translation and sleep and propose a reciprocal mechanism of dysregulation in the development of synaptic plasticity defects in neurodevelopmental disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep
/
Synapses
/
Neurodevelopmental Disorders
/
Neuronal Plasticity
Limits:
Animals
/
Humans
Language:
En
Journal:
J Comp Physiol B
Journal subject:
BIOQUIMICA
/
FISIOLOGIA
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY