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hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy.
He, Shuai; Lai, Dongwei; Ma, Chenggong; Meng, Chunren; Cai, Chunyang; Chen, Qian; Gu, Chufeng; Qiu, Qinghua.
Affiliation
  • He S; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
  • Lai D; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science & Photomedicine, Shanghai Engineering Center for Precise Diagnosis & Treatment of Eye Diseases, Shanghai, PR China.
  • Ma C; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
  • Meng C; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science & Photomedicine, Shanghai Engineering Center for Precise Diagnosis & Treatment of Eye Diseases, Shanghai, PR China.
  • Cai C; Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China.
  • Chen Q; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
  • Gu C; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science & Photomedicine, Shanghai Engineering Center for Precise Diagnosis & Treatment of Eye Diseases, Shanghai, PR China.
  • Qiu Q; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Epigenomics ; 16(7): 427-444, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38410923
ABSTRACT

Objective:

To elucidate the role of the competitive endogenous RNA (ceRNA) network in immune infiltration of diabetic retinopathy (DR).

Methods:

We obtained differentially expressed (DE) circRNAs, miRNAs and mRNAs from the Gene Expression Omnibus database. Then, we identified immune infiltration by CIBERSORT and single-sample gene set enrichment analysis and discovered co-expression genes by weighted gene co-expression network analysis. Furthermore, STAT1-mediated Th1 differentiation was determined in DR cell models, DR patients and DR mouse models.

Results:

hsa_circ_0087100/hsa-miR-6743-5p/STAT1 was involved in immune infiltration of Th1 cells. Aberrant expression of the ceRNA network and STAT1-mediated Th1 differentiation was thus verified in vitro and in vivo.

Conclusion:

hsa_circ_0087100/hsa-miR-6743-5p/STAT1 may affect Th1 cell differentiation in DR.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Th1 Cells / Diabetic Retinopathy / RNA, Circular Limits: Animals / Humans Language: En Journal: Epigenomics Year: 2024 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Th1 Cells / Diabetic Retinopathy / RNA, Circular Limits: Animals / Humans Language: En Journal: Epigenomics Year: 2024 Document type: Article Country of publication: United kingdom