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Generation of induced pluripotent stem cell line NIMHi010-A from dermal fibroblast cells of a healthy individual.
Dash, Suravi Sasmita; Arunachal, Gautham; Nimonkar, Madhura Milind; Vengalil, Seena; Nashi, Saraswati; Chetan, Ghati K; Boddu, Vijay Kumar; Nalini, Atchayaram; Markandeya, Yogananda S.
Affiliation
  • Dash SS; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
  • Arunachal G; Department of Human Genetics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India.
  • Nimonkar MM; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
  • Vengalil S; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
  • Nashi S; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
  • Chetan GK; Department of Human Genetics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India.
  • Boddu VK; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
  • Nalini A; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
  • Markandeya YS; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Electronic address: yogananda@nimhans.ac.in.
Stem Cell Res ; 76: 103355, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38412659
ABSTRACT
In this study, we have established human induced pluripotent stem cell (hiPSC) line, NIMHi010-A of a 42-year-old healthy donor. The iPSC line was generated from human dermal fibroblasts using Sendai viruses carrying reprogramming factors c-MYC, SOX2, KLF4, and OCT4 under a feeder-free culture system. The generated hiPSC line expressed typical pluripotency markers, displayed a normal karyotype, and demonstrated the potential to differentiate into the three germ layers. This hiPSC line will serve as a healthy control model for physiological processes and drug screening of Asian origin from Indian population.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Induced Pluripotent Stem Cells Limits: Adult / Humans Language: En Journal: Stem Cell Res Year: 2024 Document type: Article Affiliation country: India Country of publication: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Induced Pluripotent Stem Cells Limits: Adult / Humans Language: En Journal: Stem Cell Res Year: 2024 Document type: Article Affiliation country: India Country of publication: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM