The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification.
Neurochem Res
; 49(7): 1628-1642, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38416374
ABSTRACT
Heterotopic ossification (HO) is a pathological process characterized by the aberrant formation of bone in muscles and soft tissues. It is commonly triggered by traumatic brain injury, spinal cord injury, and burns. Despite a wide range of evidence underscoring the significance of neurogenic signals in proper bone remodeling, a clear understanding of HO induced by nerve injury remains rudimentary. Recent studies suggest that injury to the nervous system can activate various signaling pathways, such as TGF-ß, leading to neurogenic HO through the release of neurotrophins. These pathophysiological changes lay a robust groundwork for the prevention and treatment of HO. In this review, we collected evidence to elucidate the mechanisms underlying the pathogenesis of HO related to nerve injury, aiming to enhance our understanding of how neurological repair processes can culminate in HO.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ossification, Heterotopic
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurochem Res
Year:
2024
Document type:
Article
Affiliation country:
China