Flap Reconstruction Results in Longer Overall Treatment Time in Patients Treated With Surgery and Adjuvant Radiotherapy for Carcinoma of the Oral Cavity and Larynx.
Am J Clin Oncol
; 47(7): 305-310, 2024 07 01.
Article
in En
| MEDLINE
| ID: mdl-38421015
ABSTRACT
OBJECTIVE:
There is an inverse relationship between cancer cure and overall treatment time (OTT) in patients treated with surgical resection and radiotherapy (RT).METHODS:
OTT was evaluated based on the reconstruction procedure in 420 patients with oral cavity and larynx cancers treated with surgery and RT between 1991 and 2020.RESULTS:
With OTT >85 days, the difference between no versus yes flap reconstruction was ~20 percentage points and significant for all comparisons primary closure (+/- skin graft), 49%, vs. rotation or free flap, 71% ( P <0.0001); primary closure (+/- skin graft), 49%, versus free flap without bone, 66% ( P =0.0358); and primary closure (+/- skin graft), 49%, versus free flap with bone, 82% ( P <0.0001).CONCLUSIONS:
The use of flap reconstructions results in substantial increases in OTT. Findings suggest a need to reevaluate current policies regarding the choice of reconstruction and starting RT sooner after surgery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Laryngeal Neoplasms
/
Plastic Surgery Procedures
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Clin Oncol
Year:
2024
Document type:
Article
Country of publication:
United States