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Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, Sampurna; Klich, Jasmin D; Khallaf, Mohammed A; Hulme, Amy J; Sánchez-Carranza, Oscar; Baran, Zuzanna M; Rossi, Alice; Huang, Angela Tzu-Lun; Pohl, Tobias; Fleischer, Raluca; Fürst, Carina; Hammes, Annette; Bégay, Valérie; Hörnberg, Hanna; Finol-Urdaneta, Rocio K; Poole, Kate; Dottori, Mirella; Lewin, Gary R.
Affiliation
  • Chakrabarti S; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Klich JD; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Khallaf MA; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Hulme AJ; Department of Zoology and Entomology, Faculty of Science, Assiut University, Assiut 71516, Egypt.
  • Sánchez-Carranza O; School of Medical, Indigenous and Health Sciences, Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia.
  • Baran ZM; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Rossi A; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Huang AT; Molecular and Cellular Basis of Behavior, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Pohl T; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Fleischer R; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Fürst C; Molecular and Cellular Basis of Behavior, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Hammes A; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Bégay V; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Hörnberg H; Molecular Pathways in Cortical Development, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Finol-Urdaneta RK; Molecular Pathways in Cortical Development, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Poole K; Molecular Physiology of Somatic Sensation Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Dottori M; Molecular and Cellular Basis of Behavior, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin-Buch, Germany.
  • Lewin GR; NeuroCure Cluster of Excellence, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Science ; 383(6686): 992-998, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38422143
ABSTRACT
Touch perception is enabled by mechanically activated ion channels, the opening of which excites cutaneous sensory endings to initiate sensation. In this study, we identify ELKIN1 as an ion channel likely gated by mechanical force, necessary for normal touch sensitivity in mice. Touch insensitivity in Elkin1-/- mice was caused by a loss of mechanically activated currents (MA currents) in around half of all sensory neurons activated by light touch (low-threshold mechanoreceptors). Reintroduction of Elkin1 into sensory neurons from Elkin1-/- mice restored MA currents. Additionally, small interfering RNA-mediated knockdown of ELKIN1 from induced human sensory neurons substantially reduced indentation-induced MA currents, supporting a conserved role for ELKIN1 in human touch. Our data identify ELKIN1 as a core component of touch transduction in mice and potentially in humans.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sensory Receptor Cells / Mechanotransduction, Cellular / Touch Perception / Ion Channels / Mechanoreceptors / Membrane Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Science Year: 2024 Document type: Article Affiliation country: Germany Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sensory Receptor Cells / Mechanotransduction, Cellular / Touch Perception / Ion Channels / Mechanoreceptors / Membrane Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Science Year: 2024 Document type: Article Affiliation country: Germany Country of publication: United States