Total Synthesis of Dynobactin A.
J Am Chem Soc
; 146(10): 6444-6448, 2024 03 13.
Article
in En
| MEDLINE
| ID: mdl-38427590
ABSTRACT
The first total synthesis of the potent antimicrobial agent dynobactin A is disclosed. This synthesis enlists a singular aziridine ring opening strategy to access the two disparate ß-aryl-branched amino acids present within this complex decapeptide. Featuring a number of unique maneuvers to navigate inherently sensitive and epimerizable functional groups, this convergent approach proceeds in only 16 steps (LLS) from commercial materials and should facilitate the synthesis of numerous analogues for medicinal chemistry studies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amino Acids
/
Anti-Infective Agents
Language:
En
Journal:
J Am Chem Soc
/
Journal of the american chemical society
/
J. am. chem. soc
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States