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Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies.
Shida, Ryutaro; Iwakura, Takamasa; Ohashi, Naro; Ema, Chiemi; Aoki, Taro; Tashiro, Takeshi; Ishigaki, Sayaka; Isobe, Shinsuke; Fujikura, Tomoyuki; Kato, Akihiko; Nakamura, Tomohiko; Fujigaki, Yoshihide; Shimizu, Akira; Yasuda, Hideo.
Affiliation
  • Shida R; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Iwakura T; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Ohashi N; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Ema C; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Aoki T; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Tashiro T; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Ishigaki S; Blood Purification Unit, Hamamatsu University School of Medicine, Japan.
  • Isobe S; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Fujikura T; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
  • Kato A; Blood Purification Unit, Hamamatsu University School of Medicine, Japan.
  • Nakamura T; Department of Neurology, Hamamatsu University School of Medicine, Japan.
  • Fujigaki Y; Department of Internal Medicine, Teikyo University School of Medicine, Japan.
  • Shimizu A; Department of Analytic Human Pathology, Nippon Medical School, Japan.
  • Yasuda H; First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
Intern Med ; 63(5): 699-705, 2024.
Article in En | MEDLINE | ID: mdl-38432895
ABSTRACT
A 50-year-old man diagnosed with anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) was referred to our department for the evaluation of proteinuria. A kidney biopsy revealed membranous nephropathy (MN). Immunohistochemistry for CNTN1 revealed positive granular staining along the glomerular basement membrane, confirming anti-CNTN1 antibody-associated MN. Immunofluorescence showed a full-house pattern, and several autoantibodies, such as anti-nuclear antibody, anti-double-strand DNA antibody, and anti-cardiolipin antibody, were detected in the patient's serum. Although limited autoantibodies have been investigated in some of the reported cases, a variety of autoantibodies might be produced in anti-CNTN1 antibody-associated CIDP, accompanied by MN.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerulonephritis, Membranous / Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Limits: Humans / Male / Middle aged Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2024 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerulonephritis, Membranous / Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Limits: Humans / Male / Middle aged Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2024 Document type: Article Affiliation country: Japan