Severe acute interstitial nephritis induced by α-glucosidase inhibitor miglitol in an elderly patient with type 2 diabetic nephropathy.
Intern Med
; 2024 Mar 04.
Article
in En
| MEDLINE
| ID: mdl-38432957
ABSTRACT
A 79-year-old male patient with type 2 diabetic nephropathy and hypertension was admitted to our hospital because of acute kidney injury with significantly elevated serum creatinine (8.12 mg/dL) and urinary ß2-microglobulin (ß2MG, 31,748 µg/L) levels. α-Glucosidase inhibitor (α-GI) miglitol, started two weeks prior to presentation, was discontinued because drug-induced acute interstitial nephritis (AIN) was suspected. Renal biopsy revealed AIN and diabetic nephropathy. The drug-induced lymphocyte stimulation test for miglitol was also positive. After the discontinuation of miglitol, the urinary ß2MG levels decreased to the normal range. This case raises the possibility that α-GI miglitol can worsen the renal function in patients with underlying renal dysfunction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Intern Med
/
Intern. med. (Tokyo)
/
Internal medicine (Tokyo)
Journal subject:
MEDICINA INTERNA
Year:
2024
Document type:
Article
Affiliation country:
Japan
Country of publication:
Japan