The Astrocyte: Metabolic Hub of the Brain.
Cold Spring Harb Perspect Biol
; 2024 Mar 04.
Article
in En
| MEDLINE
| ID: mdl-38438188
ABSTRACT
Astrocytic metabolism has taken center stage. Interposed between the neuron and the vasculature, astrocytes exert control over the fluxes of energy and building blocks required for neuronal activity and plasticity. They are also key to local detoxification and waste recycling. Whereas neurons are metabolically rigid, astrocytes can switch between different metabolic profiles according to local demand and the nutritional state of the organism. Their metabolic state even seems to be instructive for peripheral nutrient mobilization and has been implicated in information processing and behavior. Here, we summarize recent progress in our understanding of astrocytic metabolism and its effects on metabolic homeostasis and cognition.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cold Spring Harb Perspect Biol
Journal subject:
BIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Chile