PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients.
Biomark Med
; 18(5): 169-179, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38440866
ABSTRACT
Objective:
This study aimed to assess the value of PLK4 as a biomarker in papillary thyroid carcinoma (PTC).Methods:
This study reviewed 230 PTC patients receiving surgical resections. PLK4 was detected in tumor tissues and samples of normal thyroid gland tissues by immunohistochemistry.Results:
PLK4 was elevated in tumor tissues versus normal thyroid gland tissues (p < 0.001). Tumor PLK4 was linked with extrathyroidal invasion (p = 0.036), higher pathological tumor stage (p = 0.030), node stage (p = 0.045) and tumor/node/metastasis stage (p = 0.022) in PTC patients. Tumor PLK4 immunohistochemistry score >3 was linked with shortened disease-free survival (p = 0.026) and overall survival (p = 0.028) and independently predicted poorer disease-free survival (hazard ratio 2.797; p = 0.040).Conclusion:
Tumor PLK4 reflects extrathyroidal invasion, higher tumor stage and shortened survival in PTC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Neoplasms
/
Carcinoma
/
Carcinoma, Papillary
Limits:
Humans
Language:
En
Journal:
Biomark Med
Journal subject:
BIOQUIMICA
/
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom