Interdialytic weight gain and low dialysate sodium concentration in patients on chronic hemodialysis: a systematic review and meta-analysis.
Int Urol Nephrol
; 56(7): 2313-2323, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38446246
ABSTRACT
PURPOSE:
The present systematic review and meta-analysis aimed at evaluating the effect of low dialysate sodium concentration on interdialytic weight gain (IDWG) in chronic hemodialysis patients.METHODS:
Studies were eligible for inclusion if they were English language papers published in a peer-reviewed journal and met the following inclusion criteria (1) studies in adult patients (over 18 years of age), (2) included patients on chronic hemodialysis since at least 6 months; (3) compared standard (138-140 mmol/l) or high (> 140 mmol/l) dialysate sodium concentration with low (< 138 mmol/l) dialysate sodium concentration; (4) Included one outcome of interest interdialytic weight gain. Medline, PubMed, Web of Science, and the Cochrane Library were searched for the quality of reporting for each study was performed using the Quality Assessment Tool of Controlled Intervention Studies of the National Institutes of Health. The quality of reporting of each cross-over study was performed using the Revised Cochrane Risk of Bias (RoB) tool for cross-over trials as proposed by Ding et al.RESULTS:
Nineteen studies (710 patients) were included in theanalysis:
15 were cross-over and 4 parallel randomized controlled studies. In cross-over studies, pooled analysis revealed that dialysate sodium concentration reduced IDWG with a pooled MD of - 0.40 kg (95% CI - 0.50 to - 0.30; p < 0.001). The systematic review of four parallel, randomized, studies revealed that the use of a low dialysate sodium concentration was associated with a significant reduction of the IDWG in two studies, sustained and almost significant (p = 0.05) reduction in one study, and not significant reduction in one study.CONCLUSION:
Low dialysate sodium concentration reduces the IDWG in prevalent patients on chronic hemodialysis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium
/
Dialysis Solutions
/
Weight Gain
/
Renal Dialysis
Limits:
Humans
Language:
En
Journal:
Int Urol Nephrol
Year:
2024
Document type:
Article
Affiliation country:
Italy
Country of publication:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS