Evolution-Based Discovery of Polyketide Acylated Valine from a Cytochalasin-Like Gene Cluster in Simplicillium lamelliciola HDN13430.
J Nat Prod
; 87(4): 1222-1229, 2024 04 26.
Article
in En
| MEDLINE
| ID: mdl-38447096
ABSTRACT
Utilizing a gene evolution-oriented approach for gene cluster mining, a cryptic cytochalasin-like gene cluster (sla) in Antarctic-derived Simplicillium lamelliciola HDN13430 was identified. Compared with the canonical cytochalasin biosynthetic gene clusters (BGCs), the sla gene cluster lacks the key α,ß-hydrolase gene. Heterologous expression of the sla gene cluster led to the discovery of a new compound, slamysin (1), characterized by an N-acylated amino acid structure and demonstrating weak anti-Bacillus cereus activity. These findings underscore the potential of genetic evolution in uncovering novel compounds and indicating specific adaptive evolution within specialized habitats.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Multigene Family
/
Cytochalasins
Language:
En
Journal:
J Nat Prod
Year:
2024
Document type:
Article