Association between sarcopenia-related markers and cholelithiasis: A prospective and Mendelian randomization study.
Environ Toxicol
; 39(6): 3473-3480, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38450827
ABSTRACT
Cholelithiasis is a common digestive disease that drives a myriad of adverse complications. The correlation between sarcopenia and various digestive disorders has been extensively researched, whereas its association with cholelithiasis remains unreported. We aimed to investigate the association through prospective and Mendelian randomization (MR) analyses and establish a quantitative score reflecting the impact of sarcopenia-related markers on cholelithiasis. The prospective study involved 448 627 participants from the UK Biobank. Cox proportional hazard models were employed to investigate the correlation between sarcopenia-related markers and cholelithiasis. To quantitatively assess cholelithiasis risk, the SARCHO score was derived from a multivariable Cox model. Bidirectional two-sample MR analysis was conducted to validate the causal association. A total of 16 738 individuals developed cholelithiasis during a median follow-up of 12 years. Hazard ratios (HRs) of cholelithiasis decreased stepwise over skeletal muscle index tertiles (highest tertile reference; middle tertile 1.23, p < .001; lowest tertile 1.33, p < .001). The tertiles of grip strength showed a similar pattern. Individuals with slow walking pace had a higher risk of cholelithiasis compared to those with normal walking pace (HR 1.23; p < .001). Our SARCHO score better quantifies the risk of cholelithiasis. MR analysis showed a causal relationship between muscle mass and cholelithiasis (OR 0.81; p < .001). No causal effect of cholelithiasis on lean mass was observed. Prospective and MR analyses have consistently demonstrated an increased risk of cholelithiasis in individuals with decreased muscle mass. Additionally, SARCHO score further quantified the cholelithiasis occurrence risk. These findings provide compelling evidence for muscle strengthening in preventing cholelithiasis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholelithiasis
/
Sarcopenia
/
Mendelian Randomization Analysis
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Environ Toxicol
/
Environ. toxicol
/
Environmental toxicology
Journal subject:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States