Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis.
Mult Scler
; 30(6): 707-713, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38456445
ABSTRACT
BACKGROUND:
In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes.OBJECTIVES:
In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection.METHODS:
We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders.RESULTS:
In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations.CONCLUSION:
Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Outcome
/
Abortion, Spontaneous
/
COVID-19
/
Multiple Sclerosis
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
/
Europa
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Italy