Alterations in Cerebrospinal Fluid Urea Occur in Late Manifest Huntington's Disease.
J Huntingtons Dis
; 13(1): 103-111, 2024.
Article
in En
| MEDLINE
| ID: mdl-38461512
ABSTRACT
Background:
Huntington's disease (HD) is a neurodegenerative disorder caused by expanded cytosine-adenine-guanine (CAG) repeats in the Huntingtin gene, resulting in the production of mutant huntingtin proteins (mHTT). Previous research has identified urea as a key metabolite elevated in HD animal models and postmortem tissues of HD patients. However, the relationship between disease course and urea elevations, along with the molecular mechanisms responsible for these disturbances remain unknown.Objective:
To better understand the molecular disturbances and timing of urea cycle metabolism across different stages in HD.Methods:
We completed a global metabolomic profile of cerebrospinal fluid (CSF) from individuals who were at several stages of disease pre-manifest (PRE), manifest (MAN), and late manifest (LATE) HD participants, and compared to controls.Results:
Approximately 500 metabolites were significantly altered in PRE participants compared to controls, although no significant differences in CSF urea or urea metabolites were observed. CSF urea was significantly elevated in LATE participants only. There were no changes in the urea metabolites citrulline, ornithine, and arginine.Conclusions:
Overall, our study confirms that CSF elevations occur late in the HD course, and these changes may reflect accumulating deficits in cellular energy metabolism.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Huntington Disease
Limits:
Animals
/
Humans
Language:
En
Journal:
J Huntingtons Dis
Year:
2024
Document type:
Article
Affiliation country:
United States