A global assessment of hemostatic function of healthy allogeneic stem cell donors undergoing apheresis by rotational thromboelastometry.
Ther Apher Dial
; 28(4): 657-663, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38462734
ABSTRACT
INTRODUCTION:
Peripheral blood stem cell (PBSC) collection via apheresis requires the administration of granulocyte colony-stimulating factor (filgrastim) to stem cell donors. Several reports have shown that filgrastim administration and apheresis procedure induce a hypercoagulable state across PBSC collection, which might predispose certain donors to thrombotic complications.METHODS:
We evaluated the hemostatic functions of healthy allogeneic stem cell donors by rotational thromboelastometry (ROTEM). Blood samples from healthy donors (n = 30) were collected at defined time points before filgrastim (baseline), on the day of apheresis before and after the procedure, and 1 week after apheresis.RESULTS:
The results indicated that hemostatic changes are temporary since all parameters in both EXTEM and INTEM assays are restored to their initial values 1 week after the apheresis.CONCLUSION:
We concluded that stem cell apheresis does not induce a hypercoagulable state in healthy donors. This is the first study evaluating the hemostatic functions of stem cell donors by ROTEM.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombelastography
/
Blood Component Removal
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ther Apher Dial
Journal subject:
HEMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Turkey