Pediatric cancer patients vaccinated against SARS-CoV-2-a clinical and laboratory follow-up.
Support Care Cancer
; 32(4): 221, 2024 Mar 11.
Article
in En
| MEDLINE
| ID: mdl-38467829
ABSTRACT
BACKGROUND:
Vaccination against SARS-CoV-2 is recommended for cancer patients. However, long-term data on the effectiveness in the pediatric setting are lacking.METHODS:
Pediatric patients < 18 years on active treatment for cancer and without prior SARS-CoV-2 infection received three doses of an mRNA vaccine. The clinical course and humoral and cellular immunity were evaluated at the end of the follow-up period of ≥ 1 year after the third dose of vaccine.RESULTS:
SARS-CoV-2 infection occurred in 17 of 19 analyzed patients (median age 16.5 years) during the follow-up period (median 17 months), but no severe symptoms were seen. At ≥ 1 year after the last SARS-CoV-2 antigen exposure, 4 of 17 patients had received the recommended booster vaccine. At the end of the follow-up period, all evaluable 15 patients had anti-SARS-CoV-2 receptor-binding domain IgG antibodies. Twelve of the 15 patients had neutralizing antibody titers ≥ 110 against the Delta variant and 12/15 and 13/15 against the BA.1 and BA.5 variants, respectively. Specific T cells against SARS-CoV-2 antigens were seen in 9/13 patients.CONCLUSIONS:
Most SARS-CoV-2-vaccinated pediatric cancer patients had SARS-CoV-2 infections and limited interest in booster vaccination. At 1 year after the last antigen exposure, which was mostly an infection, humoral immune responses remained strong. TRIAL REGISTRATION German Clinical Trials Register DRKS00025254, May 26, 2021.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines
/
COVID-19
/
Neoplasms
Limits:
Adolescent
/
Child
/
Humans
Language:
En
Journal:
Support Care Cancer
/
Support. care cancer
/
Supportive care in cancer
Journal subject:
NEOPLASIAS
/
SERVICOS DE SAUDE
Year:
2024
Document type:
Article
Affiliation country:
Germany
Country of publication:
Germany