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Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Singh, Amrita; Ottavi, Samantha; Krieger, Inna; Planck, Kyle; Perkowski, Andrew; Kaneko, Takushi; Davis, Andrew M; Suh, Christine; Zhang, David; Goullieux, Laurent; Alex, Alexander; Roubert, Christine; Gardner, Mark; Preston, Marian; Smith, Dave M; Ling, Yan; Roberts, Julia; Cautain, Bastien; Upton, Anna; Cooper, Christopher B; Serbina, Natalya; Tanvir, Zaid; Mosior, John; Ouerfelli, Ouathek; Yang, Guangli; Gold, Ben S; Rhee, Kyu Y; Sacchettini, James C; Fotouhi, Nader; Aubé, Jeffrey; Nathan, Carl.
Affiliation
  • Singh A; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.
  • Ottavi S; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Krieger I; Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX 77843, USA.
  • Planck K; Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
  • Perkowski A; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kaneko T; Global Alliance for TB Drug Development, New York, NY 10005, USA.
  • Davis AM; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Suh C; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.
  • Zhang D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.
  • Goullieux L; Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
  • Alex A; AMG Consultants Limited, Camburgh House, 27 New Dover Road, Canterbury, Kent, CT1 3DN, UK.
  • Roubert C; Evenor Consulting Limited, The New Barn, Mill Lane, Eastry, Kent CT13 0JW, UK.
  • Gardner M; Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
  • Preston M; AMG Consultants Limited, Camburgh House, 27 New Dover Road, Canterbury, Kent, CT1 3DN, UK.
  • Smith DM; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Ling Y; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Roberts J; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.
  • Cautain B; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.
  • Upton A; Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
  • Cooper CB; Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
  • Serbina N; Global Alliance for TB Drug Development, New York, NY 10005, USA.
  • Tanvir Z; Global Alliance for TB Drug Development, New York, NY 10005, USA.
  • Mosior J; Global Alliance for TB Drug Development, New York, NY 10005, USA.
  • Ouerfelli O; Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX 77843, USA.
  • Yang G; Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Gold BS; Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Rhee KY; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.
  • Sacchettini JC; Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
  • Fotouhi N; Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX 77843, USA.
  • Aubé J; Global Alliance for TB Drug Development, New York, NY 10005, USA.
  • Nathan C; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sci Adv ; 10(11): eadj6406, 2024 Mar 15.
Article in En | MEDLINE | ID: mdl-38489355
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Thiophenes / Transferases (Other Substituted Phosphate Groups) / Mycobacterium tuberculosis / Neoplasms Limits: Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Thiophenes / Transferases (Other Substituted Phosphate Groups) / Mycobacterium tuberculosis / Neoplasms Limits: Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States