Thin-cap fibroatheroma in acute coronary syndrome: Implication for intravascular imaging assessment.
Int J Cardiol
; 405: 131965, 2024 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-38492863
ABSTRACT
Acute coronary syndrome (ACS), a significant cardiovascular disease threat, has garnered increased focus concerning its etiological mechanisms. Thin-cap fibroatheroma (TCFA) are central to ACS pathogenesis, characterized by lipid-rich plaques, profuse foam cells, cholesterol crystals, and fragile fibrous caps predisposed to rupture. While TCFAs may be latent and asymptomatic, their pivotal role in ACS risk is undeniable. High-resolution imaging techniques like Optical coherence tomography (OCT) and Intravascular ultrasound (IVUS) are instrumental for effective TCFA detection. Therapeutic strategies encompass pharmacological and interventional measures, including antiplatelet agents, statins, and Percutaneous Coronary Intervention (PCI), aiding in plaque stabilization, inflammation reduction, and rupture risk mitigation. Despite the strong correlation between TCFAs and adverse prognoses in ACS patients, early detection and rigorous treatment significantly enhance patient prognosis and diminish cardiovascular events. This review aims to encapsulate recent advancements in TCFA research within ACS, covering formation mechanisms, clinical manifestations, and prognostic implications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ultrasonography, Interventional
/
Tomography, Optical Coherence
/
Acute Coronary Syndrome
/
Plaque, Atherosclerotic
Limits:
Humans
Language:
En
Journal:
Int J Cardiol
Year:
2024
Document type:
Article
Affiliation country:
China