Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial.
Arch Phys Med Rehabil
; 105(8): 1464-1470, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38493909
ABSTRACT
OBJECTIVE:
To compare the characteristics of responders and nonresponders to 8 weeks of exercise training to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD).DESIGN:
Secondary analysis of data from the HIIT or MISS UK trial.SETTING:
Six outpatient National Health Service cardiac rehabilitation (CR) centers in the UK. In people with CAD attending CR, the HIIT or MISS UK trial reported that short-term, low-volume, high-intensity interval training (HIIT) was more effective than moderate-intensity steady state (MISS) exercise training for improving peak oxygen uptake (VÌo2peak).PARTICIPANTS:
382 participants with CAD (N=382) (mean age 58.8±9.6y; mean body mass index 29.0±4.3 kg/m2). MAIN OUTCOMEMEASURES:
We identified responders and nonresponders based on a meaningful change in VÌo2peak, using 2 established methods. Key clinical, quality of life (QoL), and cardiopulmonary exercise test (CPET)-derived outcomes were compared between groups.RESULTS:
Responders were more likely to be younger (P<.05), and demonstrate greater improvement in CPET-related outcomes, for example, oxygen uptake efficiency slope, ventilatory efficiency, and peak power output (all comparisons, P<.001). Responders were more likely to observe improvements in QoL (EQ-5D-5L; mean Δ 13.6 vs mean Δ 9.4; P=.045), and high-density lipoprotein cholesterol (HDL-c) (mean Δ 0.09 mmol/L vs mean Δ 0.04 mmol/L; P=.004), compared to nonresponders.CONCLUSIONS:
In people with CAD attending CR, responders to exercise training were more likely to be younger and demonstrate greater improvements in health-related QoL and HDL-c.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen Consumption
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Quality of Life
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Coronary Artery Disease
/
High-Intensity Interval Training
Limits:
Aged
/
Female
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Humans
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Male
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Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Arch Phys Med Rehabil
Year:
2024
Document type:
Article
Country of publication:
United States