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Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups.
Kobayakawa, Takuya; Takano, Hikaru; Ishii, Takahiro; Bolah, Peter; Tsuji, Kohei; Ohashi, Nami; Nomura, Wataru; Furuta, Toshiaki; Tamamura, Hirokazu.
Affiliation
  • Kobayakawa T; Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
  • Takano H; Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
  • Ishii T; Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
  • Bolah P; Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
  • Tsuji K; Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
  • Ohashi N; Department of Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University.
  • Nomura W; Department of Genome and Biomolecular Engineering for Drug Discovery, School of Pharmaceutical Sciences and Graduate School of Biomedical & Health Sciences, Hiroshima University.
  • Furuta T; Department of Biomolecular Science, Faculty of Science, Toho University.
  • Tamamura H; Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
Chem Pharm Bull (Tokyo) ; 72(3): 311-312, 2024.
Article in En | MEDLINE | ID: mdl-38494724
ABSTRACT
An improvement of the two-photon excitation was achieved using 8-azacoumarin-type caged compounds, which showed large values of the two-photon uncaging action cross-section (δu >0.1 Goeppert-Mayer (GM)). In particular, the 7-hydroxy-6-iodo-8-azacoumarin (8-aza-Ihc)-caged compound showed an excellent uncaging action cross-section value (δu = 1.28 GM). Therefore, 8-azacoumarin-type photolabile protecting groups (PPGs) can be used as two-photon excitation sources.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photons Language: En Journal: Chem Pharm Bull (Tokyo) Year: 2024 Document type: Article Country of publication: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photons Language: En Journal: Chem Pharm Bull (Tokyo) Year: 2024 Document type: Article Country of publication: Japan