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Neuroanatomical variability associated with early substance use initiation: Results from the ABCD Study.
Miller, Alex P; Baranger, David A A; Paul, Sarah E; Garavan, Hugh; Mackey, Scott; Tapert, Susan F; LeBlanc, Kimberly H; Agrawal, Arpana; Bogdan, Ryan.
Affiliation
  • Miller AP; Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
  • Baranger DAA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, United States.
  • Paul SE; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, United States.
  • Garavan H; Department of Psychiatry, University of Vermont Lamer College of Medicine, Burlington, VT, United States.
  • Mackey S; Department of Psychiatry, University of Vermont Lamer College of Medicine, Burlington, VT, United States.
  • Tapert SF; Department of Psychiatry, University of California San Diego, San Diego, CA, United States.
  • LeBlanc KH; Division of Extramural Research, National Institute on Drug Abuse, Bethesda, MA, United States.
  • Agrawal A; Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
  • Bogdan R; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, United States.
medRxiv ; 2024 Mar 08.
Article in En | MEDLINE | ID: mdl-38496425
ABSTRACT
The extent to which neuroanatomical variability associated with substance involvement reflects pre-existing risk and/or consequences of substance exposure remains poorly understood. In the Adolescent Brain Cognitive DevelopmentSM (ABCD®) Study, we identify associations between global and regional differences in brain structure and early substance use initiation (i.e., occurring <15 years of age; nsanalytic=6,556-9,804), with evidence that associations precede initiation. Neurodevelopmental variability in brain structure may confer risk for substance involvement.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: MedRxiv Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: MedRxiv Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States