Fecal microbiota transplant on Escherichia-Shigella gut composition and its potential role in the treatment of generalized anxiety disorder: A systematic review.
J Affect Disord
; 354: 309-317, 2024 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-38499070
ABSTRACT
BACKGROUND:
The gut-brain-axis has a role in mental health disorders. In people with generalized anxiety disorder, GAD,1 normal flora Escherichia-Shigella, are significantly elevated. Fecal microbiota transplant, FMT,2 has been used to alter the gut composition in unhealthy individuals. There may be a role for FMT in the treatment of GAD to improve the gut-brain-axis.METHODS:
A systematic review of literature was conducted on articles published in PubMed, CINAHL Plus, Scopus, Cochrane Library, and Wed of Science from 2000 to 2022 that analyzed FMT as a modality to alter the gut microbiome in which Escherichia-Shigella levels were quantified and reported.RESULTS:
Of 1916 studies identified, 14 fit criteria and were included. Recipients undergoing FMT procedures had at least one enteric diagnosis and increased percentages of Escherichia-Shigella pre-FMT. Five studies on recurrent Clostridioides difficile infection, three irritable bowel syndrome, two ulcerative colitis, one ulcerative colitis and recurrent Clostridioides difficile infection, one acute intestinal and chronic graft-vs-host disease, one pouchitis, and one slow transit constipation. 10 articles (71.4 %) showed decreased levels of Escherichia-Shigella post-FMT compared to pre-FMT. Four studies claimed the results were significant (40 %).LIMITATIONS:
Limitations include potential bias in study selection, study methods of analysis, and generalization of results.CONCLUSIONS:
The gut-brain-axis has a role in GAD. Those with GAD have significantly higher Escherichia-Shigella compared to those without GAD. FMT has the potential to decrease Escherichia-Shigella in patients with GAD to positively alter the gut-brain-axis as a potential for future GAD treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety Disorders
/
Fecal Microbiota Transplantation
/
Gastrointestinal Microbiome
Limits:
Humans
Language:
En
Journal:
J Affect Disord
Year:
2024
Document type:
Article
Country of publication:
Netherlands