Assessment of Female Hormonal Influence on COVID-19 Vaccine Response: A Prospective Cohort Study.
Cureus
; 16(2): e54417, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38510901
ABSTRACT
INTRODUCTION:
The diversity of oral epithelial cells offers potential viral infection sites. The lower level of ACE2 inhibitors in women's blood renders them more resistant to coronavirus disease 2019 (COVID-19). In order to determine the effect of COVID-19 vaccination on female hormones, salivary levels of total antibody, immunoglobulin G (IgG), and cortisol were measured in young and elderly women.METHODS:
Saliva samples from 88 participants were collected and subjected to ELISA for detecting total antibody, IgG, and cortisol.RESULTS:
Women who were infected with COVID-19 and who completed two doses of vaccination had more IgG antibodies when compared to the uninfected individuals/single-dose/non-vaccinated individuals. The cortisol levels in post-menopausal women were higher than those in women with normal menstrual cycles, and the difference was statistically significant (P-value 0.00). The increased cortisol levels were well correlated with increased levels of IgG antibodies which was statistically significant (Spearman rho P value 0.00)Conclusions:
COVID variants will continue to mutate and evolve as long as the epidemic persists. The higher cortisol and IgG antibodies produced by female hormones protect them from COVID-19 infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cureus
Year:
2024
Document type:
Article
Country of publication:
United States