Dilation of ion selectivity filters in cation channels.
Trends Biochem Sci
; 49(5): 417-430, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38514273
ABSTRACT
Ion channels establish the voltage gradient across cellular membranes by providing aqueous pathways for ions to selectively diffuse down their concentration gradients. The selectivity of any given channel for its favored ions has conventionally been viewed as a stable property, and in many cation channels, it is determined by an ion-selectivity filter within the external end of the ion-permeation pathway. In several instances, including voltage-activated K+ (Kv) channels, ATP-activated P2X receptor channels, and transient receptor potential (TRP) channels, the ion-permeation pathways have been proposed to dilate in response to persistent activation, dynamically altering ion permeation. Here, we discuss evidence for dynamic ion selectivity, examples where ion selectivity filters exhibit structural plasticity, and opportunities to fill gaps in our current understanding.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ion Channels
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Biochem Sci
Year:
2024
Document type:
Article
Affiliation country:
United States
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM