Dietary supplementation with seeds of Sesamum indicum L. (pedaliaceae) mitigates the 7,12-dimethylbenz(a)anthracene-induced breast tumor burden in rats.
J Complement Integr Med
; 21(2): 205-214, 2024 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-38515384
ABSTRACT
OBJECTIVES:
Sesamum indicum L. seeds; rich in zinc and lignans are endowed with antioxidant and immunomodulatory properties which attract research on their anticancer potential. Although many studies have reported the in vitro antitumor potential of S. indicum and its phytoconstituents, much is yet to be known about its in vivo effects. To fill this gap, the effects of dietary supplementation with seeds of S. indicum in 7,12-dimethylbenz(a)anthracene-exposed rats was assessed.METHODS:
42 rats aged 30-35 days were randomized into six groups (n=6) as follows the normal (NOR) and negative (DMBA) control groups were fed with standard diet; the positive control group (DMBA + Zinc) was fed with standard diet supplemented with commercial zinc (0.01â¯%); the test groups were fed with standard diet supplemented with S. indicum seeds in different proportions (6.25â¯, 12.5 and 25â¯%). Breast cancer was induced by a single administration of DMBA (50â¯mg/kg BW, s.c.) diluted in corn oil. The experiment lasted 20 weeks and afterward, tumor incidence; tumor burden, tumor volume, tumor micro-architecture and some biochemical parameters were evaluated.RESULTS:
As salient result, 100â¯% of rats in the DMBA group developed tumors, while rats feed with rat chow supplemented with S. indicum seeds (25â¯%) had a reduced incidence of tumors (33.3â¯%) and tumor volume (2.71â¯cm3 in sesame 25â¯% vs. 4.69â¯cm3 in the DMBA group, pË0.01). The seeds (25â¯%) also slowed DMBA-induced neoplasm expansion in mammary ducts as compared to rats of DMBA group.CONCLUSIONS:
In summary, supplementation with S. indicum seeds slowed breast tumorigenesis via its antioxidant capacity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seeds
/
Dietary Supplements
/
Sesamum
/
9,10-Dimethyl-1,2-benzanthracene
Limits:
Animals
Language:
En
Journal:
J Complement Integr Med
Year:
2024
Document type:
Article
Affiliation country:
Cameroon
Country of publication:
Germany