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Three new phthalide derivatives from culture broth of Dentipellis fragilis and their cytotoxic activities.
Ki, Dae-Won; Choi, Dae-Cheol; Won, Yeong-Seon; Lee, Seung-Jae; Kim, Young-Hee; Lee, In-Kyoung; Yun, Bong-Sik.
Affiliation
  • Ki DW; Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, 54596, Korea. dwki0916@gmail.com.
  • Choi DC; Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, 54596, Korea.
  • Won YS; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Korea.
  • Lee SJ; Division of Research Management, Department of Bioresource Industrialization, Honam National Institute of Biological Resource, Mokpo, 58762, Republic of Korea.
  • Kim YH; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Korea.
  • Lee IK; Department of Applied Biotechnology, University of Science and Technology (UST), Daejeon, 34113, Korea.
  • Yun BS; Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, 54596, Korea.
J Antibiot (Tokyo) ; 77(6): 338-344, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38519550
ABSTRACT
Three new phthalide derivatives (1‒3) together with two known compounds, erinaceolactone B (4) and hericerin III (5), were isolated from the culture broth of Dentipellis fragilis. The chemical structures of 1‒5 were determined by analyses of their 1D-, 2D-NMR, and MS. The absolute configuration of 1 was determined by CD analysis. The isolated compounds were assessed for their cytotoxic activities against A549, DU145, HCT116, and HT1080 cancer cell lines. Compounds 1‒5 showed strong cytotoxic activities against DU145, with IC50 values ranging from 14.3 to 16.1 µM. Additionally, all compounds showed moderate or weak cytotoxic activities against all cell lines except for compounds 4 and 1 which showed no cytotoxic activities against A549 and HCT116 cancer cell lines, respectively. Against HT1080 cancer cell line, only compound 2 displayed moderate cytotoxic activity.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Antineoplastic Agents Limits: Humans Language: En Journal: J Antibiot (Tokyo) / J. antibiot / Journal of antibiotics (Online) Year: 2024 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Antineoplastic Agents Limits: Humans Language: En Journal: J Antibiot (Tokyo) / J. antibiot / Journal of antibiotics (Online) Year: 2024 Document type: Article Country of publication: United kingdom