Modulating ß-catenin homeostasis for cancer therapy.
Trends Cancer
; 10(6): 507-518, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38521655
ABSTRACT
ß-Catenin is a well-established driver of many cancers; however, there are challenges in developing agents targeting ß-catenin for clinical use. Recent progress has indicated that most of the pathological changes in ß-catenin may be commonly caused by loss of protein homeostasis. Modulation of ß-catenin homeostasis, especially by hyperactivation of ß-catenin, potentially leads to robust antitumor outcomes. Here, we comprehensively dissect the protein homeostasis of ß-catenin in terms of time, compartmentalization, supramolecular assemblies, and dynamics, with emphasis on changes in ß-catenin homeostasis upon oncogenic mutations. We propose that altered ß-catenin homeostasis could be deleterious for ß-catenin-dependent cancers and that modulation of ß-catenin homeostasis offers a novel avenue for targeting ß-catenin for cancer therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beta Catenin
/
Homeostasis
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Cancer
Year:
2024
Document type:
Article