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Prevalence and causes of chronic cough in Japan.
Ishiura, Yoshihisa; Fujimura, Masaki; Ogawa, Haruhiko; Hara, Johsuke; Shintani, Hiromoto; Hozawa, Soichiro; Atsuta, Ryo; Fukumitsu, Kensuke; Inoue, Hideki; Shioya, Takanobu; Muraki, Masato; Amemiya, Tokunao; Ohkura, Noriyuki; Oribe, Yoshitaka; Tanaka, Hiroshi; Yamada, Takechiyo; Toyoshima, Mikio; Fujimori, Katsuya; Ishizuka, Tamotsu; Kagaya, Manabu; Suzuki, Takeshi; Kita, Toshiyuki; Nishi, Koichi; Ueda, Akihito; Miyata, Yoshito; Kitada, Junya; Yamamura, Kenta; Abo, Miki; Takeda, Norihisa; Shirai, Toshihiro; Tajiri, Tomoko; Yoshihara, Shigemi; Akamatsu, Taisuke; Sawaguchi, Hirochiyo; Nagano, Tatsuya; Hanada, Soichiro; Masuda, Sawako; Ohmichi, Mitsuhide; Ito, Tomoki; Sagara, Hironori; Matsumoto, Hisako; Niimi, Akio.
Affiliation
  • Ishiura Y; First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570-8507, Japan. Electronic address: ishiuray@takii.kmu.ac.jp.
  • Fujimura M; Department of Respiratory Medicine, National Hospital Organization Nanao Hospital, 8 bu 3-1 Matsuto-machi, Nanao, 926-0841, Ishikawa, Japan; Cough Clinic, Komatsu Sophia Hospital, 478 Okimachi, Komatsu, Ishikawa, 923-0861, Japan.
  • Ogawa H; Department of Respiratory Medicine, Kanazawa Kasuga Clinic, Motogiku-machi, Kanazawa, Ishikawa, 920-0036, Japan.
  • Hara J; Department of Respiratory Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
  • Shintani H; Department of Respiratory Medicine, Shintani Medical Clinic, 67-1, Ni, Sono-machi, Komatsu, Ishikawa, 923-0801, Japan.
  • Hozawa S; Department of Respiratory Medicine, Hiroshima Allergy and Respiratory Clinic, 1-9-28 Hikari-machi Higashi-ku, Hiroshima, 732-0052, Japan.
  • Atsuta R; Department of Respiratory Medicine, Akihabara Atsuta Clinic, 1-5 Kanada-Iwamotocho, 101-0033, Chiyoda, Tokyo, 101-0033, Japan.
  • Fukumitsu K; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.
  • Inoue H; Department of Respiratory Medicine, Asthma and Lung Clinic Tokyo, 5-48-2 Higashi-Nippori, Arakawa-ku, Tokyo, 116-0014, Japan.
  • Shioya T; Department of Respiratory Medicine, Nursing Care Facility Nikoniko-en, 138-1 Shimoshinjou Nakano Azabiwanuma, Akita, 010-0146, Japan.
  • Muraki M; Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.
  • Amemiya T; Department of Respiratory Medicine, Amemiya Clinic, 17-28 Yoshida-machi, Numazu, Shizuoka, 410-0836, Japan.
  • Ohkura N; Department of Respiratory Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
  • Oribe Y; Department of Respiratory Medicine, Oribe Internal Medicin Clinic, 1-5-33, Hikoso-machi, Kanazawa, Ishikawa, 920-0901, Japan.
  • Tanaka H; Department of Respiratory Medicine, NPO Sapporo Cough Asthma and Allergy Center, 15-1-32 Minami-4-jyou-Nishi, Sapporo, Hokkaido, 064-0804, Japan.
  • Yamada T; Department of Otorhinolaryngology, Head and Neck Surgery, Akita University, Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
  • Toyoshima M; Department of Respiratory Medicine, Hamamatsu Rosai Hospital, 25 Shogen-cho, Cyuou-ku, Hamamatsu, Shizuoka, 430-8525, Japan.
  • Fujimori K; Department of Internal Medicine, Agano City Hospital, 13-23 Okayamacho, Agano, Niigata, 959-2025, Japan.
  • Ishizuka T; Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan.
  • Kagaya M; KAGAYA CLINIC of Internal Medicine, 13-18 Asahikawa minami-machi, Akita, Akita, 010-0834, Japan.
  • Suzuki T; Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8677, Japan.
  • Kita T; Department of Respiratory Medicine, NHO Kanazawa Medical Center, 1-1 Shimoishibiki-machi, Kanazawa, Ishikawa 920-8650, Japan.
  • Nishi K; Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, 2-1 Kuratsuki-Higashi, Kanazawa, Ishikawa, 920-8530, Japan.
  • Ueda A; Department of Respiratory Medicine, Medical Corporation Toujinkai, Fujitate Hospital, 5-4-24 Ohmiya, Asahi-ku, Osaka, 535-0002, Japan.
  • Miyata Y; Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Kitada J; Ohmichi Clinic of Internal and Respiratory Medicine, Nihonseimei Sapporo Bldg, Kita-3, Nishi-4, Chuo-ku, Sapporo, (Hokkaido), 060-0003, Japan.
  • Yamamura K; Department of Internal Medicine, Keiju Medical Center, 94 Tomioka-cho, Nanao, Ishikawa, 926-8605, Japan.
  • Abo M; Department of Respiratory Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
  • Takeda N; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.
  • Shirai T; Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, 4-27-1 Kita-Ando, Aoi-ku, Shizuoka, 420-8527, Japan.
  • Tajiri T; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.
  • Yoshihara S; Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuka-gun, Tochigi, 321-0293, Japan.
  • Akamatsu T; Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, 4-27-1 Kita-Ando, Aoi-ku, Shizuoka, 420-8527, Japan.
  • Sawaguchi H; Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.
  • Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
  • Hanada S; Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.
  • Masuda S; Department of Otorhinolaryngology, National Hospital Organization Mie National Hospital, 357 Osato-Kubota, Tsu, Mie, 514-0125, Japan.
  • Ohmichi M; Ohmichi Clinic of Internal and Respiratory Medicine, Nihonseimei Sapporo Bldg, Kita-3, Nishi-4, Chuo-ku, Sapporo, (Hokkaido), 060-0003, Japan.
  • Ito T; First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570-8507, Japan.
  • Sagara H; Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Matsumoto H; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama, Osaka, 589-8511, Japan.
  • Niimi A; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.
Respir Investig ; 62(3): 442-448, 2024 May.
Article in En | MEDLINE | ID: mdl-38522360
ABSTRACT

BACKGROUND:

Chronic cough is one of the most common symptoms of respiratory diseases and can adversely affect patients' quality of life and interfere with social activities, resulting in a significant social burden. A survey is required to elucidate the frequency and treatment effect of chronic cough. However, clinical studies that cover all of Japan have not yet been conducted.

METHODS:

Patients who presented with a cough that lasted longer than 8 weeks and visited the respiratory clinics or hospitals affiliated with the Japan Cough Society during the 2-year study period were registered.

RESULTS:

A total of 379 patients were enrolled, and those who did not meet the definition of chronic cough were excluded. A total of 334 patients were analyzed 201 patients had a single cause, and 113 patients had two or more causes. The main causative diseases were cough variant asthma in 92 patients, sinobronchial syndrome (SBS) in 36 patients, atopic cough in 31 patients, and gastroesophageal reflux (GER)-associated cough in 10 patients. The time required to treat undiagnosed patients and those with SBS was significantly longer and the treatment success rate for GER-associated cough was considerably poor.

CONCLUSIONS:

We confirmed that the main causes of chronic cough were cough variant asthma, SBS, atopic cough, and their complications. We also showed that complicated GER-associated cough was more likely to become refractory. This is the first nationwide study in Japan of the causes and treatment effects of chronic cough.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastroesophageal Reflux / Cough-Variant Asthma Limits: Humans Country/Region as subject: Asia Language: En Journal: Respir Investig Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastroesophageal Reflux / Cough-Variant Asthma Limits: Humans Country/Region as subject: Asia Language: En Journal: Respir Investig Year: 2024 Document type: Article