Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial.
JA Clin Rep
; 10(1): 19, 2024 Mar 26.
Article
in En
| MEDLINE
| ID: mdl-38528235
ABSTRACT
BACKGROUND:
This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).METHODS:
This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.RESULTS:
Sixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention group versus 18 patients (56.2%) in the control group (adjusted hazard ratio, 0.44; 95% confidence interval, 0.20-0.95; P = 0.04).CONCLUSIONS:
This trial demonstrated a significant reduction in AKI incidence with amino acid supplementation. TRIAL REGISTRATION jRCT, jRCTs051210154. Registered 31 December 2021, https//jrct.niph.go.jp/re/reports/detail/69916.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
JA Clin Rep
Year:
2024
Document type:
Article
Affiliation country:
Japan
Publication country:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY