The Contributions of Thrombospondin-1 to Epilepsy Formation.
Neurosci Bull
; 40(5): 658-672, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38528256
ABSTRACT
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca2+ homeostasis, which are closely associated with the occurrence and development of epilepsy. In this review, we summarize the potential contributions of TSP-1 to epilepsy development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombospondin 1
/
Epilepsy
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurosci Bull
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Singapore