Are oral cancers effectively palliated with radiotherapy? Outcomes of treatment with a modified QUAD SHOT regimen.
Head Neck
; 46(6): 1270-1279, 2024 06.
Article
in En
| MEDLINE
| ID: mdl-38528774
ABSTRACT
BACKGROUND:
This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers.METHODS:
Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer.RESULTS:
Ninety-nine (85%) completed three courses. Overall subjective response rate was 77%. Median overall survival and progression-free survival were 12 months (95% confidence interval [CI] 8-20) and 8 months (95% CI 6-10), with numerically higher overall survival in oral cancer. The treatment was well tolerated, with no on-treatment hospitalization or grade 3-4 toxicities.CONCLUSION:
The modified QUAD SHOT regimen is practical for palliation in head and neck cancers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palliative Care
/
Mouth Neoplasms
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Head & neck
/
Head Neck
/
Head neck
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
India
Country of publication:
United States