Long-term outcomes of endoscopic therapy versus surgical resection for 2-5 cm gastric gastrointestinal stromal tumors: A population-based comparative study.
Eur J Surg Oncol
; 50(6): 108262, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38531231
ABSTRACT
BACKGROUND:
Endoscopic therapy (ET) of gastrointestinal stromal tumors (GIST) has become a viable treatment. We intended to compare long-term outcomes of ET versus surgical resection for 2-5 cm GIST using the Surveillance, Epidemiology, and End Results (SEER) database.METHODS:
A multicenter retrospective study was conducted to compare the long-term outcomes of patients treated with ET and surgical resection for GIST. The multivariate Cox proportional hazards models were used to identify predictors for patients survival. To balance the clinicopathologic characteristics, a 11 propensity score matching (PSM) was utilized.RESULTS:
A total of 749 patients with 2-5 cm GIST were enrolled, of whom 113 accepted ET and 636 underwent surgical resection. Before PSM, there was no significant difference in long-term outcomes between ET and surgical resection (5-year overall survival (OS) 93.5% vs. 91.6%, P=0.374; 5-year cancer-specific survival (CSS) 99.1% vs. 96.5%, P=0.546; 10-year OS 71.1% vs. 78.2%, P=0.374; 10-year CSS 93.6% vs. 92.7%, P=0.546). After adjusting for the relevant variables using the multivariable Cox proportional hazards models, we observed that the ET and surgical resection groups were similar in OS (HR 0.726, 95%CI 0.457-1.153, P=0.175) and CSS (HR 1.286, 95%CI 0.474-3.488, P=0.621). After PSM, the long-term OS and CSS of patients with 2-5 cm GIST after ET and surgical resection were comparable.CONCLUSIONS:
We found that the long-term survival of patients with 2-5 cm gastric GIST after ET and surgical resection were comparable. Further high-quality studies are needed to confirm the role of ET in 2-5 cm GIST.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
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SEER Program
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Gastrointestinal Stromal Tumors
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Propensity Score
Limits:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Eur J Surg Oncol
/
Eur. j. surg. oncol
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European journal of surgical oncology
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom