Diagnostic utility of cytology in a patient with Epstein-Barr virus-positive mucocutaneous ulcer in palatine tonsils: A case report.
Diagn Cytopathol
; 52(7): E154-E158, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38533980
ABSTRACT
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, dysphagia, and oral pain. His medical history included rheumatoid arthritis that had been treated with methotrexate. Clinically, peritonsillar abscess was suspected, but since neoplastic lesions, including malignant lymphoma (ML), could not be excluded, a series of cytohistological examination was attempted. Despite some alarming findings (e.g., frequent mitoses), fine-needle aspiration and touch imprint cytology consistently revealed a heterogeneous population of lymphoid and plasmacytoid cells with mild nuclear atypia. The final diagnosis of EBVMCU was established based on the permanent histologic specimen; however, retrospectively, cytology was more representative of the benign nature of the lesion than histology, helping a great deal to differentiate it from ML. Cytology can be a useful tool for the correct diagnosis of EBVMCU.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palatine Tonsil
/
Epstein-Barr Virus Infections
Limits:
Aged80
/
Humans
/
Male
Language:
En
Journal:
Diagn Cytopathol
Journal subject:
PATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Japan