Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing.
Curr Oncol
; 31(3): 1556-1561, 2024 03 19.
Article
in En
| MEDLINE
| ID: mdl-38534951
ABSTRACT
Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy. Herein, we report a case of DAP with novel genetic alterations (BCOR P1153S, ERG M219I, KDR A750E, POLE S1896P, and RAD21 T461del).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Carcinoma, Acinar Cell
/
Carcinoma, Ductal
Limits:
Humans
/
Male
Language:
En
Journal:
Curr Oncol
Year:
2024
Document type:
Article
Affiliation country:
United States