Palladium-Catalyzed Regioselective Insertion of Carbenes into γ-C(sp3)-H Bonds of Aliphatic Amines.
Org Lett
; 26(13): 2523-2528, 2024 Apr 05.
Article
in En
| MEDLINE
| ID: mdl-38536882
ABSTRACT
A migratory insertion of carbenes into distal γ-C(sp3)-H bonds of aliphatic amines has been successfully developed. The synergistic interplay among a palladium catalyst, picolinamide directing group, a carefully selected base additive, and an essential ligand proved crucial in achieving high yields. These findings hold significant value for advancing the exploration of regioselective carbene insertions into nonactivated C(sp3)-H bonds.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States