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Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.
Lu, Xiaowen; Shi, Zhan; Jiang, Lingling; Zhang, Songying.
Affiliation
  • Lu X; Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Shi Z; Department of Obstetrics and Gynecology, Key Laboratory of Reproductive Dysfunction, Management of Zhejiang Province, Hangzhou, China.
  • Jiang L; Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
  • Zhang S; Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol ; 15: 1362784, 2024.
Article in En | MEDLINE | ID: mdl-38545107
ABSTRACT
Due to the physiological alteration during pregnancy, maternal gut microbiota changes following the metabolic processes. Recent studies have revealed that maternal gut microbiota is closely associated with the immune microenvironment in utero during pregnancy and plays a vital role in specific pregnancy complications, including preeclampsia, gestational diabetes, preterm birth and recurrent miscarriages. Some other evidence has also shown that aberrant maternal gut microbiota increases the risk of various diseases in the offspring, such as allergic and neurodevelopmental disorders, through the immune alignment between mother and fetus and the possible intrauterine microbiota. Probiotics and the high-fiber diet are effective inventions to prevent mothers and fetuses from diseases. In this review, we summarize the role of maternal gut microbiota in the development of pregnancy complications and the health condition of future generations from the perspective of immunology, which may provide new therapeutic strategies for the health management of mothers and offspring.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Premature Birth / Microbiota / Gastrointestinal Microbiome Limits: Female / Humans / Newborn / Pregnancy Language: En Journal: Front Immunol Year: 2024 Document type: Article Affiliation country: China Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Premature Birth / Microbiota / Gastrointestinal Microbiome Limits: Female / Humans / Newborn / Pregnancy Language: En Journal: Front Immunol Year: 2024 Document type: Article Affiliation country: China Country of publication: Switzerland