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Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation.
Wang, Pin; Sun, Wenxian; Gong, Jin; Han, Xiaodong; Xu, Chang; Chen, Yufei; Yang, Yuting; Luan, Heya; Li, Shaoqi; Li, Ruina; Wen, Boye; Lv, Sirong; Chen, Runqi; Guo, Jinxuan; Wei, Cuibai.
Affiliation
  • Wang P; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Sun W; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Gong J; College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Han X; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Xu C; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Chen Y; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Yang Y; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Luan H; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Li S; College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Li R; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Wen B; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Lv S; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Chen R; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Guo J; College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Wei C; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China. Electronic address: weicb@xwhosp.org.
Stem Cell Res ; 77: 103398, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38552354
ABSTRACT
Genetic polymorphism of apolipoprotein E (APOE) confers differential susceptibility to Alzheimer's disease (AD), and APOE ɛ4 variants is the most powerful risk factor for this disease. Here, we report the generation of a human induced pluripotent stem cell (iPSC) line carrying the APOE ɛ4/ɛ4 genotype from peripheral blood mononuclear cells (PBMCs) isolated from a male with a family history of AD utilizing non-integrative Sendai virus vector. The iPSC maintains their original genotype, highly express endogenous pluripotency markers, displays a normal karyotype, and retains the ability to differentiate into cells representative of the three germ layers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Induced Pluripotent Stem Cells Limits: Humans / Male Language: En Journal: Stem Cell Res Year: 2024 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Induced Pluripotent Stem Cells Limits: Humans / Male Language: En Journal: Stem Cell Res Year: 2024 Document type: Article Affiliation country: China Country of publication: United kingdom