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The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection.
Rigo, Isaura; Young, Mary K; Abhyankar, Mayuresh M; Xu, Feifan; Ramakrishnan, Girija; Naz, Farha; Madden, Gregory R; Petri, William A.
Affiliation
  • Rigo I; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Young MK; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Abhyankar MM; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Xu F; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Ramakrishnan G; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Naz F; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Madden GR; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
  • Petri WA; University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA. Electronic address: wap3g@virginia.edu.
Anaerobe ; 87: 102842, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38552897
ABSTRACT
Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recurrence / Bacterial Toxins / Immunoglobulin G / Clostridioides difficile / Clostridium Infections / Antibodies, Bacterial Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Anaerobe Year: 2024 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recurrence / Bacterial Toxins / Immunoglobulin G / Clostridioides difficile / Clostridium Infections / Antibodies, Bacterial Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Anaerobe Year: 2024 Document type: Article Affiliation country: United States