Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV.
J Infect Dis
; 230(2): 421-425, 2024 Aug 16.
Article
in En
| MEDLINE
| ID: mdl-38557859
ABSTRACT
We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90â
kg and 0.98â
kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Haplotypes
/
DNA, Mitochondrial
/
Weight Gain
/
Body Mass Index
/
HIV Infections
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Infect Dis
Year:
2024
Document type:
Article
Affiliation country:
Spain
Country of publication:
United States