Synthesis and biological properties of 16(S)-amino-PGF2 alpha methyl ester.
Prostaglandins
; 29(2): 303-12, 1985 Feb.
Article
in En
| MEDLINE
| ID: mdl-3856905
ABSTRACT
A synthesis of 16-amino-derivatives of PGF2 alpha is reported. Introduction of an amino group into position 16 of PGF2 alpha has decreased the sensitivity of the compound to metabolic degradation. 16(S)-amino-PGF2 alpha methyl ester shows high abortifacient activity with reduced diarrhoeic side effect.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostaglandins F, Synthetic
/
Abortifacient Agents
/
Abortifacient Agents, Nonsteroidal
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Prostaglandins
Year:
1985
Document type:
Article