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Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2.
Kawata, Daisuke; Iwai, Hideyuki; Oba, Seiya; Komiya, Yoji; Koike, Ryuji; Miyamoto, Sho; Kanno, Takayuki; Ainai, Akira; Suzuki, Tadaki; Hosoya, Tadashi; Yasuda, Shinsuke.
Affiliation
  • Kawata D; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  • Iwai H; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  • Oba S; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  • Komiya Y; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  • Koike R; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  • Miyamoto S; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kanno T; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Ainai A; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Hosoya T; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: hosoya.rheu@tmd.ac.jp.
  • Yasuda S; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: syasuda.rheu@tmd.ac.jp.
Cytokine ; 178: 156592, 2024 06.
Article in En | MEDLINE | ID: mdl-38574505
ABSTRACT
The severity of COVID-19 has been reported to differ among SARS-CoV-2 mutant variants. The overactivation of macrophages is involved in severe COVID-19, yet the effects of SARS-CoV-2 mutations on macrophages remain poorly understood. To clarify the effects, we examined whether mutations of spike proteins (S-proteins) affect macrophage activation. CD14+ monocyte-derived macrophages were stimulated with the recombinant S-protein of the wild-type, Delta, and Omicron strains or live viral particles of individual strains. Regarding IL-6 and TNF-α, Delta or Omicron S-protein had stronger or weaker pro­inflammatory ability, respectively, than the wild-type. Similar trends were observed between S-proteins and viral particles. S-protein mutations could be related to the diversity in macrophage activation and severity rates in COVID-19 caused by various SARS-CoV-2 strains.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom