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APOE loss of function: A genetic shield against Alzheimer's disease.
Tate, Mason D; Karahan, Hande; Kim, Jungsu.
Affiliation
  • Tate MD; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Karahan H; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Kim J; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: jk123@iu.edu.
Neuron ; 112(7): 1033-1035, 2024 Apr 03.
Article in En | MEDLINE | ID: mdl-38574724
ABSTRACT
In this issue of Neuron, Chemparathy et al.1 provide human genetics data suggesting that APOE loss-of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain-of-function hypothesis for AD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Limits: Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Limits: Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States