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Targeting methionine metabolism in cancer: opportunities and challenges.
Bin, Peng; Wang, Chuanlong; Zhang, Hangchao; Yan, Yuqi; Ren, Wenkai.
Affiliation
  • Bin P; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; Henry Fok School of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
  • Wang C; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
  • Zhang H; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
  • Yan Y; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
  • Ren W; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China. Electronic address: renwenkai19@scau.edu.cn.
Trends Pharmacol Sci ; 45(5): 395-405, 2024 May.
Article in En | MEDLINE | ID: mdl-38580603
ABSTRACT
Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis. Recent studies have revealed mechanisms regulating methionine metabolism within the tumor microenvironment (TME) that drive both cancer development and antitumor immunity evasion. In this review article we summarize advancements in our understanding of tumor regulation of methionine metabolism and therapies in development that target tumor methionine metabolism. We also delineate the challenges of methionine blockade therapies in cancer and discuss emerging strategies to address them.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Microenvironment / Methionine / Neoplasms Limits: Animals / Humans Language: En Journal: Trends Pharmacol Sci Year: 2024 Document type: Article Affiliation country: China Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Microenvironment / Methionine / Neoplasms Limits: Animals / Humans Language: En Journal: Trends Pharmacol Sci Year: 2024 Document type: Article Affiliation country: China Country of publication: United kingdom