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Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases.
Zeng, Qing; Gong, Yongzhen; Zhu, Neng; Shi, Yaning; Zhang, Chanjuan; Qin, Li.
Affiliation
  • Zeng Q; Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
  • Gong Y; Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
  • Zhu N; The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410021, China.
  • Shi Y; Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
  • Zhang C; Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
  • Qin L; Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Institutional Key Laboratory of Vascular Biology and Translational Medicine in Hunan Province, Hunan University of Chinese Medicine, 
Ageing Res Rev ; 97: 102294, 2024 06.
Article in En | MEDLINE | ID: mdl-38583577
ABSTRACT
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regulate the cellular senescence process. Based on existing research evidences, the changes in lipid metabolism in senescent cells are mainly concentrated in the metabolic processes of phospholipids, fatty acids and cholesterol. Obviously, the changes in lipid-metabolizing enzymes and proteins involved in these pathways play a critical role in senescence. However, the link between cellular senescence, changes in lipid metabolism and age-related disease remains to be elucidated. Herein, we summarize the lipid metabolism changes in senescent cells, especially the senescent cells that promote age-related diseases, as well as focusing on the role of lipid-related enzymes or proteins in senescence. Finally, we explore the prospect of lipids in cellular senescence and their potential as drug targets for preventing and delaying age-related diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Cellular Senescence / Lipid Metabolism Limits: Animals / Humans Language: En Journal: Ageing Res Rev Journal subject: GERIATRIA Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Cellular Senescence / Lipid Metabolism Limits: Animals / Humans Language: En Journal: Ageing Res Rev Journal subject: GERIATRIA Year: 2024 Document type: Article