Luteolin Is More Potent than Cromolyn in Their Ability to Inhibit Mediator Release from Cultured Human Mast Cells.
Int Arch Allergy Immunol
; 185(8): 803-809, 2024.
Article
in En
| MEDLINE
| ID: mdl-38588651
ABSTRACT
INTRODUCTION:
Mast cells are known for their involvement in allergic reactions but also in inflammatory reactions via secretion of numerous pro-inflammatory chemokines, cytokines, and enzymes. Drug development has focused on antiproliferative therapy for systemic mastocytosis and not on inhibitors of mast cell activation. The only drug available as a "mast cell blocker" is disodium cromoglycate (cromolyn), but it is poorly absorbed after oral administration, is a weak inhibitor of histamine release from human mast cells, and it develops rapid anaphylaxis. Instead, certain natural flavonoids, especially luteolin, can inhibit mast cell activation.METHODS:
Here, we compared pretreatment (0-120 min) with equimolar concentration (effective dose for 50% inhibition = 100 mRESULTS:
We show that luteolin is significantly more potent than cromolyn inhibiting release of histamine, tryptase, metalloproteinase-9, and vascular endothelial growth factor. Moreover, while luteolin also significantly inhibited release of IL-1ß, IL-6, and IL-8 (CXCL8) and TNF, cromolyn had no effect.CONCLUSION:
These findings support the use of luteolin, especially in liposomal form to increase oral absorption, may be a useful alternative to cromolyn.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin E
/
Cromolyn Sodium
/
Luteolin
/
Histamine Release
/
Mast Cells
Limits:
Humans
Language:
En
Journal:
Int Arch Allergy Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
Switzerland