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Deep learning assists in acute leukemia detection and cell classification via flow cytometry using the acute leukemia orientation tube.
Cheng, Fu-Ming; Lo, Shih-Chang; Lin, Ching-Chan; Lo, Wen-Jyi; Chien, Shang-Yu; Sun, Ting-Hsuan; Hsu, Kai-Cheng.
Affiliation
  • Cheng FM; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
  • Lo SC; Artificial Intelligence Center, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
  • Lin CC; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
  • Lo WJ; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
  • Chien SY; Artificial Intelligence Center, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
  • Sun TH; Artificial Intelligence Center, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
  • Hsu KC; Artificial Intelligence Center, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan. ai@itri.org.tw.
Sci Rep ; 14(1): 8350, 2024 04 09.
Article in En | MEDLINE | ID: mdl-38594383
ABSTRACT
This study aimed to evaluate the sensitivity of AI in screening acute leukemia and its capability to classify either physiological or pathological cells. Utilizing an acute leukemia orientation tube (ALOT), one of the protocols of Euroflow, flow cytometry efficiently identifies various forms of acute leukemia. However, the analysis of flow cytometry can be time-consuming work. This retrospective study included 241 patients who underwent flow cytometry examination using ALOT between 2017 and 2022. The collected flow cytometry data were used to train an artificial intelligence using deep learning. The trained AI demonstrated a 94.6% sensitivity in detecting acute myeloid leukemia (AML) patients and a 98.2% sensitivity for B-lymphoblastic leukemia (B-ALL) patients. The sensitivities of physiological cells were at least 80%, with variable performance for pathological cells. In conclusion, the AI, trained with ResNet-50 and EverFlow, shows promising results in identifying patients with AML and B-ALL, as well as classifying physiological cells.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Deep Learning Limits: Humans Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: Taiwan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Deep Learning Limits: Humans Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: Taiwan
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