Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study.
J Bone Jt Infect
; 9(1): 87-97, 2024.
Article
in En
| MEDLINE
| ID: mdl-38601005
ABSTRACT
Introduction:
The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs).Methods:
A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel.Results:
A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88.4â¯% and 85â¯% respectively between the JI Panel and synovial fluid cultures (SFCs). The JI Panel detected more positive samples and microorganisms than SFC, with a notable difference on Staphylococcus aureus, Streptococcus species, Enterococcus faecalis, Kingella kingae, Neisseria gonorrhoeae, and anaerobic bacteria. The study found that the BIOFIRE JI Panel has a high utility in the real-world clinical setting for suspected SA and PJI, providing diagnostic results in approximately 1â¯h. The user experience was positive, implying a potential benefit of rapidity of results' turnover in optimising patient management strategies.Conclusion:
The study suggests that the BIOFIRE JI Panel could potentially optimise patient management and antimicrobial therapy, thus highlighting its importance in the clinical setting.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Bone Jt Infect
Year:
2024
Document type:
Article
Affiliation country:
France
Publication country:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY